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January 2015

NEW Automated fully-integrated filling line for vials from 5ml to 50ml

Grifols Partnership has a new automated fully-integrated filling line for pharmaceutical products subjected to terminal sterilization. The entire filling line has been designed by Grifols Engineering, and is able to fill vials from 5ml to 50ml with a production capacity of 3,000 units/hour.

The Line is composed of two separate modules:

  • The first module is composed of an inlet turntable that is feed by a depyrogenation tunnel, and a dispensing and capping module.
  • The second module has a double capping station and a system for placing the vials in racks.

Fully programmable peristaltic pumps are used to achieve the most demanding requirements in terms of dose limit and timing. The four dispensing heads are independently monitored and controlled.

A pick-and-place type station is responsible for capping the previously dispensed vials.

A measurement sensor verifies the correct placement of the caps, thus ensuring that all vials are properly covered. Vials are rejected if the sensor detects a misplaced cap, or if an error is detected in the peristaltic pumps implying a fault in the dose dispensed.

In the second module, the capped vials are encapsulated to ensure correct sealing. The capsule is laser-etched and immediately checked by a computer vision camera. If the laser etching is faulty, the vial is rejected.

Vials are automatically placed on racks.

The design of the filling line complies with strict Good Manufacturing Practice (GMP) requirements as well as the standards required by Health Authorities such as FDA and EMA

April 2014

Coming from ICSE-CPhI in Saint Petersburg

We have taken part for the first time in the CPHI Russia, which took place on the 16 and 17th April, in Saint Petersburg. It is considered the number one pharma sourcing event, and the ideal background for networking and building new contacts in the Contract Manufacturing sector, specifically in the CIS and Russian territories.

Grifols International took part in the exhibition, where the company stand was used to promote Grifols Engineering activity focus in construction of pharmaceutical plants and Laboratorios Grifols focus in the contract manufacturing of sterile solutions and lipid emulsions

Once more, we have had an positive impression of our participation, having established key contacts with potential partners.